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Researcher with lab equipment

Research centers, facilities & equipment

Chemistry research centers enable faculty and their student teams to engage in ongoing interdisciplinary projects, funded in part by federal grants and foundation support.

Center for Computational Biology and Bioinformatics

The Center for Computational Biology and Bioinformatics brings world-class, cutting-edge research in these areas to Indiana with special emphasis on the problems of identifying the functions and structures of various protein entities in a manner that stimulates both academic and commercial collaborations.

Visit the Center for Computational Biology and Bioinformatics for more information.

Director:

Keith Dunker, Ph.D., IU School of Medicine

Center for Structural Biology

The Center for Structural Biology is a multi-disciplinary center for experimental investigations designed to examine the structural and functional characteristics of biological macromolecules and how these changes in these properties relate to specific diseases. Projects currently under investigation are examining the underlying mechanisms for alcoholism, cancer, diabetes, liver and heart disease.

Visit the Center for Structural Biology site for more information.

Chemical Synthesis and Organic Drug Lead Development

Given the increased demand for customized chemical syntheses of drug leads and biological probes on the IUPUI campus, the Department of Chemistry & Chemical Biology of the School of Science has joined forces with the IU Simon Cancer Center to create a core facility for Chemical Synthesis & Organic Drug Lead Development to expedite the translational research and drug development efforts of cancer researchers.

The goal of the Synthetic Core is to support the synthetic and medicinal chemistry needs of IUSCC investigators as well as other academic entities within IUPUI and throughout the state; the core is also available to the broader life sciences industrial community of central Indiana and elsewhere on a contract basis.

Visit IU Simon Cancer Center website to learn more.


Director: Eric C. Long, Ph.D.

Director of Synthesis: Tax M. Georgiadis, Ph.D.

Indiana Institute for Biomedical Imaging Sciences

The mission of the Indiana Institute for Biomedical Imaging Sciences is to promote human health through the application of advanced biomedical imaging technologies. The institute will serve the academic, medical, and business communities of Indiana by:

  1. Serving as a focal point for multi-institutional collaboration in basic and applied research to develop novel biomedical imaging technologies.
  2. Serving as a focal point for the creation of discipline specific research programs focused on the application of biomedical imaging to further our knowledge about specific diseases or classes of diseases and human disorders.
  3. Maintaining a state-of-the-art Biomedical Imaging facility that enables basic, applied, and clinical investigators access to advanced imaging capabilities.
  4. Providing educational programs to promote biomedical imaging across the basic, applied, and clinical sciences.
  5. Maintaining a Life Sciences economic development program that supports the provision of advanced imaging services to industry, the formation of companies that provide products for health care services, the transfer of novel technologies to the medical industry, and supports technology development R&D.
  6. Maintaining an interface for optimized access and utilization of imaging resources across partner institutions in clinical trials.
  7. Maintaining advanced technical support staff to implement and support advanced imaging technologies on systems located in clinical imaging centers.

Visit the Indiana Institute for Biomedical Imaging Sciences site for more information.

Indiana University Melvin and Bren Simon Cancer Center

The Indiana University Melvin and Bren Simon Cancer Center is a patient care, research, and educational organization within the Indiana University School of Medicine, located on the school's main campus in Indianapolis.

Established in 1992 as the IU Cancer Center, it has been an NCI-designated Cancer Center since 1999 and is the only center with such distinction in Indiana that provides patient care. It changed its name in 2006 to reflect the philanthropic support of the Melvin and Bren Simon family.

Our physicians and scientists are primarily faculty of the IU School of Medicine, but also include representatives from the schools of nursing and dentistry as well as the Purdue School of Science at IUPUI.

Our physicians combine their resources and talents, working together as a team with patients, nurses, allied health professionals, as well as basic and behavioral scientists to address the full spectrum of patient needs - physical as well as emotional, psychological and spiritual.

Our research is vigorous, innovative and devoted to taking an improved cancer care into the future.

And our educational programs ensure that this innovation and quality of care become the mantra of the health professionals and scientists of tomorrow.

Our mission is to advance the understanding, prevention and treatment of cancer throughout Indiana and the world with patient-centered care, acceleration of promising science and collaborative educational programs.

The benefits to our patients are clear: a wide range of innovative treatment options, expert teams of diverse professionals focused on their specific cancer type, and attention to all cancer care needs in one setting.

Visit the Indiana University Cancer Center site for more information.

Center for Nuclear Magnetic Resonance

Using the techniques of nuclear magnetic resonance, the Nuclear Magnetic Resonance Center conducts basic and applied research on metabolism, and on structure-function relationships of biological macromolecules.

Visit the Nuclear Magnetic Resonance Center site for more information.

Directors:

  • B. D. Nageswara Rao, Ph.D.
  • Bruce D. Ray, Ph.D.

Major Departmental Instrumentation

NMR

  • Bruker Avance III 500 MHz NMR (with solid-state analysis and magic angle spinning capabilities, a 1.7 mm inverse probe, 5mm triple resonance inverse probe, 5mm broadband probe, and a 60 sample sample-changer allowing remote data acquisition and processing).
  • Varian Gemini 2000 200 MHz FT-NMR
  • Varian Inova 500 MHz NMR (via the Nuclear Magnetic Resonance Center)

Mass Spectrometry

  • Agilent 6890-5973 GC-MS System
  • Agilent 7890-5975C GC-MS System with an FID detector
  • Agilent 1100-6130 LC-MS (2 instruments)
  • Agilent 1200-6410 LC-MS (rapid resolution HPLC with a triple quadrupole mass spectrometer)
  • Agilent 1200-6520 LC-MS (Capillary HPLC with a quadrupole-time-of-flight mass spectrometer 

Separations

  • Agilent 1100 Series LC system (2 instruments)
  • Agilent 6890 GC with FID detector
  • Varian CP-3800 GC with FID and TCD detectors
  • Beckman Optima L-70 Ultracentrifuge
  • Beckman J2-6KR Refrigerated Centrifuges (2 instruments)

Spectral Analysis

  • Agilent 1100 Series LC system (2 instruments)
  • Thermo-Nicolet iS10 FT-IR
  •  Thermo-Nicolet 380 FTIR (2 instruments)
  • Thermo-Nicolet 300 FT-IR
  • Varian Cary Eclipse Fluorescence Spectrophotometer
  • Jasco J-720 CD Spectropolarimeter
  • Perkin Elmer Lambda 19 UV-Vis-Near IR Spectrophotometer
  • Thermo NanoDrop 2000 UV-Vis Spectrophotometer
  • Thermo Evolution 600 UV-Vis Spectrophotometer
  • Thermo Genesys 10 UV-Vis Spectrophotometers (2 instruments)
  • Agilent 8453 UV-Vis Spectrophotometer
  • Perkin Elmer 2380 Atomic Absorption Spectrophotometer
  • ICP (via the Department of Geology)
  • Siemens/Bruker AXS D5000 Automated Powder X-ray Diffractometer (via the Department of Geology)

Other

  • Schoeffer LH 151-N/1S High Intensity Photolysis Apparatus
  • Johnson Matthey MK2 Magnetic Susceptibility Balance
  • NIMA PS4 Surface Pressure Balance
  • Innovative Technologies Lab Master 100 Glovebox
  • CHI 760D Electrochemical workstation

The Department also maintains a variety of more routine instrumentation.

Biochemistry Biotechnology Facility (BBF)

The Biochemistry Biotechnology Facility (BBF) offers an automated DNA sequencing service which can be used for sequence of analysis of plasmid, PCR, and large DNA samples. This service utilizes a Perkin Elmer/Applied Biosystems 3100 Genetic Analyzer and Big Dye Terminator chemistry v3.1.

Visit the Biochemistry Biotechnology Facility site for more information.

Computational Molecular Science Laboratory

The Laboratory for Computational Molecular Science maintains 2 Silicon Graphics High Resolution Graphics Workstations and offers an array of molecular modeling and quantum mechanical software.

Software available:

Hardware available:

  • Dell work station- 2
  • Mac work station- 2
  • SG work station- 2

The Department also maintains numerous microcomputer workstations, superminicomputers, and monochrome/color high-resolution printers. There are about 1000 additional micros/UNIX workstations available to students at public clusters throughout the University. Virtually all campus computers are connected by a major fiber optic ethernet backbone with ready access to the World Wide Web. IUPUI is also a core site for the Abilene Internet 2 Project.

Mass Spectrometry Facility

The Department of Chemistry and Chemical Biology operates a mass spectrometry (MS) facility to provide top-quality MS support for students and researchers. We currently specialize in walk-up MS analysis for GC-MS and LC-MS to provide hands-on MS instrumentation training. Instruments currently available for walk-up use include:

  • an Agilent 6890-5973 GC-MS;
  • an Agilent 7890-5975 GC-FID/GC-MS;
  • an Agilent 1100-6130A LC-MS with ESI; and,
  • an Agilent 1100-6130B LC-MS with ESI and APCI capabilities.

This facility also contains an Agilent 1200SL-6410 rapid resolution LC-Triple Quad MS with sensitivity upgrade and an Agilent 1200-6520 capillary LC-Q-TOF MS. These two instruments were obtained through a National Science Foundation grant to support multiple research efforts at IUPUI. While they are not currently available for walk-up use, arrangements can be made for sample analysis by staff, or researcher training for larger projects if instrument time is available. The facility also contains a SpectrumMill MS proteomics workbench, Bioconfirm, Mass Profiler, Mass profiler Professional and a METLIN database for data analysis.

Please contact Dr. Karl Dria (317-274-6879 or kdria@iupui.edu) with any questions.

Nanoscale Imaging Center

The Nanoscale Imaging Center (NIC) completes the existing biomedical imaging capabilities at IUPUI, the Indiana Center of Excellence in BioMedical Imaging (IN-CEBI) with its whole body imaging focus and the Indiana Center for Biological Microscopy with its cellular level imaging focus. The NIC anchors a campus effort to investigate the behavior of single molecules and nanostructures, with an emphasis on medical, biological, and materials science applications.

NIC focus includes the broad areas of:

  • Subcellular imaging
  • Biomimetics for biomaterials and biosensors
  • Nanotechnology and development of next generation nanoscale imaging probes and instrumentation

 

Directors:

Instructional Facilities

Chemistry Resource Center

Workshop Chemistry Program

Workshops (or Peer Led Team Learning) are experiences in active learning. Students work together to solve problems and to reveal where difficult or obscure steps might be, allowing them to cooperatively progress through the learning exercise.

It has been demonstrated in many studies on learning that the outcome far exceed the independent learner. Why? Students study and communicate with each other, which results in a higher level of understanding than that of students who study alone. When students work together to solve problems, they reinterpret ideas and concepts in alternative and unanticipated ways. This process improves learning for students at all levels.

At the same time, students learn to be part of team--a frequent expectation of future employers. Our own research here at IUPUI shows that we have experienced as high as a 60% increase in students receiving C or better grades compared to the past with students participating in traditional recitations.

Students who become peer leaders experience better performance in subsequent chemistry classes, and better performance on standardized tests. Learn more about workshop leaders.

The C105 Workshops are two-hour active-learning sessions in which students in the course will practice doing challenging problems collaboratively. Chemistry content, communication skills and good teamwork practices will be emphasized in these peer-led sessions and students will be expected to be active participants. Learn more about the C105 Workshops.

 

 

Chemistry major makes the most of opportunities to get involved

Stephanie Metcalf Chemistry, Undergraduate