Nature Inspired Sensors: Multifunctional Biphotonic Nanostructures Inspired By the Longtail Glasswing Butterfly for Medical DevicesSpeaker: Thakshila Liyanage, PhD Candidate, Department of Chemistry & Chemical Biology, IUPUI Location: 402 N Blackford St. Indianapolis, IN 46202 LD 010
Glaucoma is the major cause of irreversible blindness worldwide and this disease damage the optical nerve in the eye mostly due to elevated intraocular pressure (IOP). According to the statistics, the number of people affected by open-angle glaucoma and angle-closure glaucoma is expected to rise from 60.5 million in 2010 to 79.6 million in 2020. Therefore, there is an emerging requirement to find effective glaucoma screening and treatment to prevent the vision loss in the first place. However, the current diagnose method involved measuring the IOP through contact with the cornea (exterior of the eye) effectively ‘poking’ the eye to read the resistance to deflection using rebound tonometer. The tonometer could cause significant occurrences of false measurements of IOP due to its incapacity to adjust the individual variations in corneal elasticity. To eliminate this issue Narasimhan et al. have reported at nature nanotechnology, the properties of multifunctional bio-inspired nanostructures (BINS) and their potential application as implantable sensors to assist glaucoma diagnosis and therapy. Here, they have demonstrated the use of transparent photonic nanostructure which has inspired by the longtail glasswing butterfly (Chorinea faunus) as IOP sensor in vivo. Accordingly, They have obtained the nanostructured features on top of a Si3N4 substrate via phase separation between two immiscible polymers (poly(methyl methacrylate) and polystyrene). Finally, they have utilized this photonic membrane as an optomechanical sensing element to develop the microscale implantable IOP sensor. Further, they have performed in vivo testing on New Zealand white rabbits and successfully demonstrated that their device reduces the mean IOP measurement variation compared with conventional rebound tonometry without signs of inflammation.
1. Narasimhan, V.; Siddique, R. H.; Lee, J. O.; Kumar, S.; Ndjamen, B.; Du, J.; Hong, N.; Sretavan, D.; Choo, H., Multifunctional biophotonic nanostructures inspired by the longtail glasswing butterfly for medical devices. Nature Nanotechnology 2018, 13 (6), 512-519.