New Alkene Difunctionalization Reactions for Organic SynthesisSpeaker: John Wolfe, PhD, Professor of Chemistry, University of Michigan Location: 402 N Blackford St. Indianapolis, IN 46202 LD 010
Two recently developed Pd-catalyzed alkene difunctionalization reactions will be described. The first involves the coupling of alkenes bearing pendant aryl/alkenyl triflate electrophiles with nitrogen-, oxygen-, or carbon-centered electrophiles to afford carbocyclic product. The second involves the coupling of N-allylureas or N-allylguanidines with O-acylated hydroxylamines, which act as nitrogen centered electrophiles, to afford heterocyclic alkene diamination products. Details of the development, stereocontrol, and reaction mechanisms of these transformations will be discussed.