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Orthogonal Chemistry for Forming Dynamic Extracellular Matrices

Speaker: Chien-Chi Lin, Associate Professor, Department of Biomedical Engineering, IUPUI Location: 402 N Blackford St. Indianapolis, IN 46202 LD 010

Host: Naumann

​Polymeric hydrogels are increasingly used as biomimetic scaffolds for delivering cells and drugs to facilitate tissue regeneration. Hydrogel matrices with defined properties are also highly desirable as platforms for studying cell biology in three-dimension (3D). Over the past few years, my laboratory has focused on designing polymeric hydrogels with controllable biophysical (e.g., stiffness, degradability, permeability, etc.) and biochemical properties (e.g., cell signaling ligands) for a variety of biomedical applications. In particular, we are interested in hydrogels prepared from orthogonal ‘photo-click’ chemistry, including thiol-norbornene and thiol-allylether hydrogels that are amenable to both long-wavelength ultraviolet and visible light initiated crosslinking processes. Moreover, we are designing new hydrogels whose mechanical properties can be dynamically and reversibly controlled. In addition to investigating and improving material properties of these ‘thiol-X’ hydrogels, we are also interested in using these modular and dynamic hydrogels for identifying individual factors and signals regulating cell fate processes in 3D. In this talk, I will highlight our recent efforts on the development of modular biomimetic hydrogels for modeling pancreatic cancer cell growth and epithelial-mesenchymal transition (EMT).